Airemwen C.O
Dr, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, NigeriaPublications
-
Research Article
Formulation of an Optimised Glimepiride Compression Coated Tablets for Chronotherapeutic Drug Delivery
Author(s): Airemwen C.O*, Uhumwangho M.U and Obakpolor S.O
Background: Chronopharmaceutics is an aspect of pharmaceutics devoted to the formulation of drug delivery systems that release their active ingredients at a rhythm that ideally matches the physiological requirement of a particular disease condition. Objective: The aim of the present study is to formulate an optimized coated glimepiride time release tablets (CGTRT) containing glimepiride, a third generation sulphonylurea in the inner core for chronotherapeutic drug delivery system. Method: Glimepiride core tablets (GCT) containing Anacardium occidentale gum (10 %w/w) as binder and maize starch as disintegrant (10 %w/w) were prepared at compression pressure of 30 unit on the arbitrary load scale. CGTRT containing Anacardium occidentale gum powder with sodium starch glycolate at varying concentration (0.5%, 1%, 2%, 4%, and 6%w/w) were also prepared at 30 unit.. Read More»