Investigation of Antiangiogenic Activity of Cassia Fistula Extract In Chick Embryo Chorioallantoic Membrane Model
Abstract
Arunkumar Choulam, Ravi Kumar Bothala, Prashanth R.
Plant which harbors curative elements or properties in one or more of its parts may be termed has medicinal plant. Plant based medicaments have been employed since the dawn of civilization for prolonging the life of man for combating against various body ailments. So medicinal plants like Cassia Fistula have their different pharmacological activities so they are cultivating in many places of India. Cassia fistula has been reported to have different pharmacological effects like Antiinflammatory, Antifungal activity, Antibacterial Activity, Antihelminthic Activity along with these effects it also has Antiangiogenic effect. Which used in the treatment of cancer. The study was conducted to investigate the scientific basis for the traditional use of Cassia fistula by determining its Antiangiogenic effect in chorioallantoic membrane assay (CAM assay). Cassia fistula was evaluated for antiangiogenic activity by chorioallantoic membrane assay (CAM assay). Antiangiogenic effect was assessed using Cassia fistula induced hypotensive rat. Antiangiogenic effect was evaluated in hypotensive rat, in comparison to control group with the standard (salicylic acid) and test (Cassia fistula) group showed significant activity. Antiangiogenic activity was evaluated in CAM assay, in comparison to control group with the test group showed significant activity of less angiogenesis. From the present study it can be concluded that ethanolic extract of Cassia fistula shown Antiangiogenic activity.
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