Expression of IGF-2 Receptor In Salivary Gland Tumors and Its Correlation with Tumor Relapse
Abstract
Emamverdizadeh P1, Vosough Hosseini S1, Farnia S*1, Shokouhi Gavgani B2, Dehghan Manshadi V3, Lotfi R4.
Background: Pleomorphic Adenoma (PA) is one of the most common benign salivary gland neoplasms, whereas mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are the most common malignant salivary gland tumors (SGT). The expression of insulin-like growth factor receptors (IGF-R) plays an important role in the pathophysiology of different neoplasms. Since there is a lack of sufficient data on the importance of IGF-R in the pathogenesis of SGTs, the present study aimed at evaluating the IGF-2R expression and its correlation with tumor relapse in three common SGT diseases. Methods: In a laboratory study, 44 paraffin-embedded specimens (15 in PA, 14 in MEC, and 15 in ACC groups) were studied. The samples were stained for IGF-2R using polyclonal antibody. The expression of IGF-2 receptor was studied by two pathologists, and the patients were observed for any evidence of relapse. Data analysis was done by SPSS 18, and p<0.05 was considered as statistically significant. Results: Out of the 44 enrolled patients, 25 (56.8%) were male. The meanïÃ?â??Ã?â??±SD age was 38.8ïÃ?â??Ã?â??±13.72, 47.07ïÃ?â??Ã?â??±14.95, and 51.26ïÃ?â??Ã?â??±14.31 years in the PA, MEC, and ACC groups, respectively. No significant difference was observed in the positive cells for IGF-2R between the three groups, whereas the difference for staining intensity and calculated scale was found to be statistically significant (p=0.02, p=0.04, respectively). Tumor relapse was reported to be higher in ACC compared to the MEC and PA groups (p<0.01). The relationship among staining intensity, calculated scale, and the tumor relapse was statistically remarkable (p=0.02). Conclusion: The results of the present study concluded that the relapse rate of tumors is related to IGF-2R expression in tumor cells. The relapse rate was higher and the expression of IGF-2R was lower in ACC when compared to the PA and MEC types of SGTs.
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