Development of Controlled Drug Delivery System for a Traditional Medicine and Study of Its Antimicrobial Property
Abstract
Lopamudra Bhattacharyya1*, Pratip Kumar Debnath1, Joyram Hajra1, Sachchida Nand Upadhyay1, Manoj Kumar Mitra2
Development of a novel drug delivery system to provide sustainable and controlled release of a traditional Ayurvedic medicine, Makaradhwaja (enhances the power of immunity and prevents inflammatory and degenerative changes) has been attempted by using the process of encapsulation into nano porous silica gel matrix. Following entrapment of Makaradhwaja, the synthesized gels have been subjected to characterization by FTIR, HRTEM and UV-visible spectroscopic analysis. FTIR and HRTEM studies had been done to authenticate the presence of drug molecule into the gel matrix. In FTIR spectrum the broad peaks at 3474 cm-1and 1637 cm-1 are detected due to the presence of Makaradhwaja into silica gel. The entrapment has also been proved by the HRTEM image. Release kinetics in a Simulated Body Fluid (SBF) has been subsequently observed and the UV-visible spectroscopy reveals up to 50% release of drug molecule in the Simulated Body Fluid (SBF) in 240 hours. The significant antimicrobial activity of the formulation had been observed against three pathogenic bacterial strains i.e. Escherichia coli, Klebsiella pneumonia and Staphylococcus aureus by using disc diffusion method Acute oral toxicity study on mice had been done and throughout the two weeks of the treatment no significant changes had been observed in behavioral pattern, clinical sign and body weight of the animals. All data indicates that the formulation could be used as bioactive controlled drug delivery systems.
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