Development and Evaluation of Niosomal Formulation of Famciclovir
Abstract
Vandana Arora Sethi*1, Abdul W. Siddiqui 2, Govind Mohan3
Niosomes are one of the best and most effective among these carriers system. Because of the presence of hydrophilic, lipophilic and amphiphilic moieties in the structure, these niosomes can accommodate various drug molecules with a wide range of solubility. So, these may act as a depot, releasing the drug in a defined manner. Rationale behind the present study is to improve the oral bioavailability of Famciclovir by preparing niosomes. Encapsulation of Famciclovir in lipophilic vesicular structure may be expected to enhance the dissolution, oral absorption and prolong the existence of the drug in the systemic circulation. The niosomal dispersions were formulated using various combinations of cholesterol and spans. The formulations were evaluated in-vitro and in-vivo and compared with the marketed preparation of Famciclovir.
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