Antiparkinsonian Drug Utilization Pattern and ADR Monitoring In a Tertiary Care Teaching Hospital: A Hospital Based Observational Study
Abstract
Monalisa Jena1, Subhransu Sekhar Jena2, Swati Mishra1, Subrat Kumar Tripathy3, Iswar Chandra Behera4
Introduction: Parkinson’s disease (PD) is chronic progressive neurodegenerative disorder represented by tetrad of symptoms such as bradykinesia, tremor, rigidity and gait disturbances. It results from the degeneration of dopamine-generating cells in the substantia nigra in midbrain. This study was done to determine the prescribing pattern of antiparkinsonian drugs and associated adverse drug reactions in patients. Materials & methods: Data was collected from the case sheets in retrospective manner from Department of neurology of IMS & SUM Hospital, Bhubaneswar, India. The demographic profile, disease duration, symptoms, categories of drug, adverse drug reaction if any were noted and analyzed. Results: Male predominance was seen. A majority of patients were between 51 and 80 years and most of the patients had onset of disease between 51 and 80 years. The common presenting symptoms were rigidity, tremor and bradykinesia. The commonest category of drug prescribed was levodopa either as monotherapy or in combination with other agents. Levodopa induced dyskinesia was the most common adverse drug reaction. The number of adverse drug reactions was significantly higher among patients receiving combination therapy. Conclusion: This study enlightens our knowledge regarding the utilization profile of antiparkinsonian drugs and related adverse drug reactions.
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