• Qualitative Assessment and Investigation of Antifungal Activity of Methanolic and Petroleum Ether Extracts of Tectona Grandis Linn Seeds

      Tectona grandis has been claimed to be useful in treatment of microbial and fungal infections and the current literature survey revealed that no systematic approach has been made towards documentation of this claim. The currently available synthetic antimicrobial agents are associated with numerous serious side effects like hypersensitivity, crystalluria, photosensitivity, hepatic and renal damage, ototoxicity, neurotoxicity etc. These adverse effects either restrict the continuation of therapy or demand for additional drug/s to combat them. This in turn indicates the need of alternative value addition therapy. In light of this, Methanolic and Petroleum ether extract of Tectona grandis was screened for its antifungal activity by using fungal culture but none of extracts were found to be significant in this regard. The claim mentioned in an ancient period may be of value especially in absence of today’s effective antifungal agents. As far as today’s minimum standard required, it cannot be promoted as antifungal as per these observation. Download
    • Qualitative Assessment and Investigation of Antifungal Activity of Methanolic and Petroleum Ether Extracts of Tectona Grandis Linn Seeds

      Tectona grandis has been claimed to be useful in treatment of microbial and fungal infections and the current literature survey revealed that no systematic approach has been made towards documentation of this claim. The currently available synthetic antimicrobial agents are associated with numerous serious side effects like hypersensitivity, crystalluria, photosensitivity, hepatic and renal damage, ototoxicity, neurotoxicity etc. These adverse effects either restrict the continuation of therapy or demand for additional drug/s to combat them. This in turn indicates the need of alternative value addition therapy. In light of this, Methanolic and Petroleum ether extract of Tectona grandis was screened for its antifungal activity by using fungal culture but none of extracts were found to be significant in this regard. The claim mentioned in an ancient period may be of value especially in absence of today’s effective antifungal agents. As far as today’s minimum standard required, it cannot be promoted as antifungal as per these observation. Download
    • Quantitative Analysis of Almotriptan Malate by UV Spectrophotometric Method Development

      Aim/background: A simple, rapid, precise, and economical spectrophotometric method has been developed for the quantitative estimation of Almotriptan Malate in pharmaceutical formulation Materials and Methods: The simple, precise, economical and rapid method was developed and validated for the estimation of Almotriptan Malate using 0.1N HCl as a solvent. The stock solution of Almotriptan Malate was prepared and subsequent suitable dilution was prepared in 0.1N HCl to obtained standard curve. The standard solution of Almotriptan Malate showed two absorption maxima, one at 283.000 nm and another at 283.00 nm. Results: The drug obeyed beer lambert’s law in the concentration range of 10-100 µg/ mL with regression 0.9998 at 283.00 nm. The overall % recovery was found to be 99.82% which reflects that the method is free from interference of the impurities and other additives used in formulation. The low value of % RSD was indicative of accuracy and reproducibility of the method. The %RSD for interday and intraday precision was found to be 0.1874 and 0.3612, respectively which is <2% hence proved that method is precise. Conclusions: The results of analysis have been validated as per ICH guidelines. The developed method can be adopted in routine analysis of Almotriptan Malate in tablet dosage form as well bulk dosage form Download