• Harmonization in Microbial Limit Test of USP and EP

      The harmonized versions have been published and it’s continuing till both the country is ready for harmonization. Japan is also included in harmonization process. The harmonized chapters do not differ in most case from the drafts published in 2003 .This article briefly describes harmonized USP chapters {61} microbial enumeration , {62} absence of specified micro organism, {1111} microbiological attributes to no sterile pharmaceutical product .The format of USP chapters changes drastically with this harmonization whereas the microbial limit tests were two chapters in USP 29(5,6) they are now modified now in modified version to copy the European version. It is most important to the people who want to carry out the tests in both the country and want to export product in both country. The implementation of the tests was in different schedule in US and in Europe. Download
    • Hazards in Modern Dentistry – A Review

      Despite numerous advances in recent years in the field of dentistry, many occupational health problems still persists. They include stress and professional burnout, allergies from various materials, musculoskeletal disorders and diseases of peripheral nervous system, Percutaneous Exposure Incidents (PEI),biological hazards, hazards due to nitrous oxide and legal hazards. Dental professionals are constantly exposed to a number of specific occupational hazards. In many cases, this exposure results in diseases which are regarded as occupational illnesses. Based on the relevant literature, this review focuses on the occupational hazards in dentistry. Being unaware of the potential hazards in the work environment makes dental personnel vulnerable to occupational injury and illnesses. Awareness of these occupational hazards and implementation of preventive strategies can provide a safe dental environment of all concerned. Download
    • Hospital Acquired Infections in Different Wards of Patna Medical College & Hospital

      Nosocomial infection - also called “hospital acquired infection” this includes infections acquired in the hospital but appearing after discharge, and also occupational infections among staff of the facility. The most common types of Nosocomial infections that could occur in a hospital are surgical wound and other soft tissue infections, Urinary tract infections, Respiratory infections, Gastroenteritis, Meningitis. Naturally this work was undertaken with a view to study the problems of postoperative sepsis and other types of infection during hospitalization period and to express more knowledge over this subject. The samples of Pus, Urine, Sputum and Swab Samples from the different parts of the hospitals were collected. These were then cultured into the different media. After the specific duration the cultural and morphological characters were noted. The organism were identified on the basis of characters of the colony, Gram staining, Motility test, Biochemical reactions & coagulase tests. In Burn wound infection it was observed that most sensitive antibiotics against all above mention organism were Piperacillin, Gentamysin, Amikacin. In Noscomial urinary tract infection E. coli was the most common microorganism isolated and showed most sensitivity to Ceftazidime. Staphylococcus aureus was the most common organism isolated from surgical wards and it was most sensitive with the Cefotaxime. From respiratory tract infection most common organism was Staphylococcus aureus and most sensitive antibiotics was Imipenem. Download
    • Human Lung Cancer: Molecular Inconsistencies and Therapeutic Consequences

      Human Lung cancer is the main reason for cancer related death and hence a significant health issue. The effectiveness of current therapy modalities for lung cancer depends firmly on the time of opinion, with better risks of survival if a tumour has been identified at an early stage. Along these lines, there is a pressing requirement for fast and effective early recognition method. Albeit most lung malignancies are the outcome of smoking, a significant fraction of molecular epidemiological studies point to high-predominance, low-penetrance genetic polymorphisms as modifiers of natural lung cancer hazard. Recently the genomics field has additionally made critical advances in distinguishing genetic lesions that can now be reaped with the objective of recognizing novel biomarkers for lung cancer. Novel high-throughput, quantitative measures for the discovery of DNA methylation or histone tail alterations are currently applied, to look for changes in the lung cancer genome and will distinguish novel cancer related genes that may get to be alluring focuses for treatment, give new understanding into the science of lung cancers, and could likewise get to be valuable biomarkers for the early recognition of lung cancer in saliva, or may be utilized as prognostic biomarkers. Download