• Ocular Drug Delivery System & Role of Ocular Inserts In Eye Disorder Treatment: A Review

      Eye is the organ of human body having main function of vision. Ocular drug delivery is the alternative route for the systemic treatment of disease and also a route for the treatment of eye diseases such as conjunctivitis, keratitis etc. Ocular inserts are the one of the most useful and innovative technique for the treatment of eye diseases by increase contact time and providing control release of drug. This review is generated to provide an overview of ocular drug delivery including role of ocular inserts in treatment of eye disorders. Download
    • Osmotically Controlled Oral Drug Delivery Systems – A Review

      Osmotic drug delivery systems are new approach for a modified release dosage form. Various innovations and patents available for various types of osmotic drug delivery system. The review is concerned with the drug release study of tablets coated with walls of controlled porosity. Drugs can be delivered in a controlled pattern over a long period of time by osmotic process. These devices are the most promising strategy and most reliable controlled drug delivery system as oral drug delivery systems. In this paper, mechanism of osmosis, principle of osmosis, factors affecting drug release, types of pumps and materials used, evaluation, various types of osmotic drug delivery systems and the basic components have been discussed briefly. Download
    • Osmotic Controlled Drug Delivery Systems: An Overview

      Osmotic controlled drug delivery systems utilize the principles of osmotic pressure for the controlled delivery of active agent. The delivery rate of zero-order is achievable with these systems. The release rate from these systems is highly predictable and can be programmed by modulating the release control parameters. The drug release from these systems is independent of gastric pH and hydrodynamic conditions. A high degree of in vivo-in vitro correlation (IVIVC) is obtained with osmotically controlled drug delivery systems. In this review various types of osmotic systems, basic components, patent literature and commercially marketed osmotic drug delivery systems are discussed. Download
    • Outcome of Liver Transplantation in Indian Patients

      The liver is self-regenerative organ. Liver can regenerate in weeks or month to its original volume. Even a large part of liver can be removed from donor then remaining part of liver is sufficient to perform the metabolic need of the patients. Therefore, a healthy person can donate part of his/her liver for LT. In India many children’s need the Liver transplant were referred are very late stage. After that also the socio economic condition and lack of donor are the two important factors in the transplantation. The study had aim to focus on the background of liver transplant in India. Also the critical observation after the liver transplantation is reported. The observation of the children’s liver transplant observed are the bile leak, acute rejection, venos thrombosis, hypertension and bacterial sepsis. Download
    • Optimization of Formulation of Gastroretentive Drug Delivery System Containing Atenelol

      Floating dosage form is an oral dosage form that is designed to prolong the residence time of dosage form within the GI tract. It is formulation of a drug and gel forming hydrocolloids meant to remain buoyant on stomach contents. The purpose of this investigation was to optimize the formulation of gastroretentive drug delivery system of Atenelol. Atenelol is a drug of choice for the treatment of hypertension and it is a ß-1 cardio selective adrenergic receptor blocker. Optimization of formulation of floating tablets of Atenelol was done depending upon three different factors such as controlled drug release of drug, floating characteristics and hardness of tablets. This was carried out by studying the effect of different proportions of the polymers, effervescent and different compression pressure. Semi-synthetic polymers HPMC-K100M and a natural polymer, Xanthan gum were used to assess the effect on the release of drug. Dicalcium phosphate was used as a channeling agent. Sodium bicarbonate was used as a gas generating agent. Evaluation of powder blends like angle of repose, bulk density, Carr’s index and Hausner’s ratio was evaluated. Atenelol floating tablets were evaluated for In vitro dissolution and floating lag time. Evaluation of tablets i.e. diameter, thickness, friability, hardness, average weight and content uniformity were performed. Drug release from the tablets was sufficiently sustained. Download
    • Oil Extraction from Matured Seeds of Cassia Tora and its Nutritional, Antioxidative Properties

      The matured seed of Cassia tora was analyzed to extract oil content to determine nutritional and antioxidant properties. The seed oil extracted by the steam distillation method, the nutritional profile, free radical scavenging and phosphomolybdenum reduction assay were also determined. The seed derived extracted oil (41.8%) contained free fatty acids 22.15±1.71%, total amino acids 21.09±1.69%, unsaturated fatty acids of oleic acid (13.31±1.72%), linoleic acid (11.25±1.13%), palmitic acid (12.78±1.21%) and total amino acid. The seed oil possessed significant free radical scavenging activity of IC50 (28.78±0.69) and phosphomolybdenum reduction (52.4±4.32), which was equal to that of rutin (31.56±0.81) as synthetic antioxidant drug. The result of this study revealed that the oil extracted from matured seeds possess reduced fatty acids, higher unsaturated fatty acids, more content of amino acids, free radical scavenging ability and phosphomolybdenum reduced properties. In conclusion, the Cassia tora seed oil may be used as edible in human health and also used for various treatments of rheumatoid, cardiovascular disease and nutritional deficiency. Download