• Leptin Association in Disease and Disorders

      Leptin, a peptide molecule first identified through its role in the hypothalamus regulating food intake and body weight. In addition to the adipose tissue, leptin is expressed in lymphoid tissues, placenta, ovaries, mammary epithelium and bone marrow. Leptin binds to leptin receptor (ObR), which was first isolated from the choroid plexus by expression cloning strategies. ObRs (6 isoforms) are located in the central nervous system and peripheral tissues and show structural similarity with cytokines. Most of the physiological actions of leptin including feeding and energy balance. The other roles of leptin are in reproduction, thermogenesis, synaptic plasticity and neuroprotective effects. In conclusion, this review discusses leptinsignaling in different brain areas and sheds light on the involvement of leptin in neurodegenerative disorders. Leptin has neuroplastic and neurotrophic effects and can be definitely useful for treating such diseases. Leptin may have an additional benefit as an insulin sensitizer but, further research is required to elucidate whether leptin sensitizers will be useful and if leptin has a major role in treating brain disorders. Better understanding of the mechanisms mediating leptin's neurodevelopmental actions and increased knowledge about the vulnerability of the brain to leptin level changes is needed. Download
    • Liquisolid: A Novel Technique for Dissolution Enhancement of Poorly Water Soluble Drugs

      Liquisolid compact technology is a novel concept for oral drug delivery. Liquisolid compact technology was first described by spireas et.al. (1998).This technique was used for water insoluble drugs. Solubility is a major problem for nearly one third drugs in their development phase. Liquisolid technique is a most promising technique for promoting dissolution by increase in solubility. It was found that the increase in oral bioavailability of poorly water soluble drug. The liquisolid system formed by conversion of liquid drug, drug suspension, drug solution using non- volatile solvent in to dry, non-adherent free flowing and compressible powder mixture by blending the drug suspension or solution with selected carrier and coating material it produce solid powder . This powder is evaluated for angle of repose, liquid load factor, compressibility test. Then such powder is subjected for tableting. The prepared tablet evaluate for hardness, friability, disintegration time, content uniformity, dissolution study, weight variation. On the basis of current literature survey it can be concluded that the liquisolid compact technique is promising alternative to enhance dissolution rate by increasing its solubility there by it may increase bioavailability of poorly water soluble, water insoluble, liquid drugs. Therefore this technique is potentially safe and efficacious method. Hence it can be applied for large scale manufacturing. Download
    • Liposphere Lipid Based Drug Delivery System :A Review

      New chemical entities (NCEs) in modern discovery libraries and development programs have an ever-increasing number of unconventional physical and chemical properties. In particular, up to 70% of discovery compounds and 40% of pipeline candidates are insoluble in water. These promising molecules present unique formulation and development challenges and often suffer from poor bioavailability. Therefore, conventional formulation systems cannot be employed. Techniques available for scientists to increase the bioavailability of poorly soluble drugs are either increasing their solubility in biological media of choice, or increasing their dissolution kinetics. The use of advanced lipid-based drug delivery systems (LBDDS) is a strategy to design pharmaceutical dosage forms with improved therapeutic benefits. Download